SP702A PRAGMATIC TRIAL OF DELAYED-RELEASE CYSTEAMINE BITARTRATE IN CHILDREN LESS THAN 6 YEARS OLD WITH CYSTINOSIS
نویسندگان
چکیده
منابع مشابه
Twice-daily cysteamine bitartrate therapy for children with cystinosis.
OBJECTIVE Cystinosis causes renal and other organ failure. Regular 6-hourly cysteamine bitartrate (Cystagon; Mylan, Morgantown, West Virginia) reduces intracellular cystine and the rate of organ deterioration. A formulation of cysteamine requiring less frequent dosing may improve compliance and possibly patient outcome. METHODS Enteric-release cysteamine was prepared. For a period of 1 month,...
متن کاملQuality of Life is Improved and Kidney Function Preserved in Patients with Nephropathic Cystinosis Treated for 2 Years with Delayed-Release Cysteamine Bitartrate
OBJECTIVES To determine the long-term effects of delayed-release cysteamine bitartrate (DR-CYS) based on our previous work that established the short-term noninferiority of DR-CYS every 12 hours compared with immediate-release cysteamine bitartrate every 6 hours. STUDY DESIGN We conducted a prospective, controlled, open label, single-arm study of DR-CYS for 2 years in 40 patients to assess ef...
متن کاملBRIEF REPORT Treatment of cystinosis with delayed-release cysteamine: 6-year follow-up
Background Patients with nephropathic cystinosis are required to take 6-hourly immediate-release cysteamine (Cystagon®) to reduce disease progression. This arduous regimen affects quality of life, disrupts sleep, and may result in noncompliance with therapy. Enteric-coated cysteamine bitartrate (EC-cysteamine) was developed as a “proof-of-concept” formulation for twice-daily ingestion. Previous...
متن کاملA randomized controlled crossover trial with delayed-release cysteamine bitartrate in nephropathic cystinosis: effectiveness on white blood cell cystine levels and comparison of safety.
BACKGROUND AND OBJECTIVES Immediate-release cysteamine bitartrate (Cystagon; Mylan Pharmaceuticals, Canonsburg, PA) may prevent or delay kidney transplantation and other serious outcomes in patients with cystinosis, but has never been subjected to a prospective clinical trial. Cystagon efficacy requires strict lifelong dosing every 6 hours. Such a dosing schedule and Cystagon-associated side ef...
متن کاملDetection of Adnovirus in children less than 5 years old with acute gastroenteritis (AGE) from Bogota, Colombia.
Acute gastroenteritis (AGE) has a great impact on children less than five years of age, producing high levels of morbidity and mortality. Worldwide, AGE is mainly related to viruses, mainly rotavirus but human adenovirus (HAdV) in particular as an important etiologic agent. Among HAdV species F, genotypes 40 and 41 are responsible for a high number of diarrhea cases, mainly in children under 2 ...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2016
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfw179.09